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KMID : 1140120120170040344
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Cancer Prevention Research
2012 Volume.17 No. 4 p.344 ~ p.349
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Roles of the Steroid Receptor Coactivator-3 in Lung Cancer
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Kwak In-Seok
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Abstract
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The steroid receptor coactivator-3 (SRC-3) interacts with nuclear receptors and facilitates target gene transcription and plays important roles in different types of tumors. However, little is known regarding the functional roles of SRC-3 in lung cancer progression. In order to elucidate the functional role of SRC-3 in lung cancer progression, Clara cell-specific lung cancer transgenic mice with SRC-3 null background have been generated. The majority of multifocal adenocarcinomas were localized in the Clara cells or the periphery of Clara cells in these mice. According to measurements of tumor area, no significant difference in tumor progression was exhibited due to genetic ablation of the SRC-3 gene. In addition, no significant phenotype differences or obvious pulmonary-related diseases were observed in the lung of the SRC-3 null mutant mice. However, tumor incidences, represented by numbers of tumor foci in SRC-3 null mice, were slightly higher than those of wild type mice. Interestingly, the expression of SRC-3 is only observed in the normal Clara cells, not in transformed Clara cells or multifocal adenocarcinoma areas. In conclusion, unlike tumors of other tissues such as breast and ovary cancer, SRC-3 does not play a pivotal role in lung tumor progression, especially in invasiveness of Clara cell derived lung cancer.
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KEYWORD
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Steroid receptor coactivator-3, Lung cancer, Clara cell specific protein
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